Master’s Thesis Project in Alcohol use disorder at Neuropsykiatrisk Laboratorium

Master’s Thesis Project at Laboratory of Neuropsychiatry

GLP-1 in alcohol withdrawal – Can a diabetes medication cure alcohol dependence?

3.3 million deaths worldwide annually are attributed to alcohol use; in Denmark, an estimated 14% of the adult population has a harmful use of alcohol. Although available therapies can be effective in some drinkers, most relapse to drinking. Glucagon-like peptide 1 (GLP-1) is a peptide that is produced in the intestinal tract and regulates blood sugar and food intake, and GLP-1 receptor agonists are used clinically to manage type 2 diabetes and obesity. GLP-1 is also produced in the brain, and GLP-1 receptor agonists are being investigated as a treatment for alcohol dependence. When people stop drinking, withdrawal symptoms contribute to relapse, and can be harmful in themselves. It is not known how GLP-1 receptor agonists affect this important phase of the addiction cycle.

Assays and Techniques: The project uses a combination of behavioral approaches (operant behaviors, withdrawal symptoms such as anxiety-like behaviors and depression- like behaviors) with classical pharmacology in rodents (systemic or brain region-specific drug administration), and neurochemistry assays (including extracting brains and preparing tissue homogenates, immunochemistry, HPLC).

Qualifications: You are a highly motivated Masterʼs student in the field of molecular biomedicine, pharmacology, human biology, or related disciplines. Completed course in Laboratory Animal Science mandatory.

Laboratory of Neuropsychiatry: We are a research unit at Psychiatric Centre Copenhagen, Region Hovedstadens Psykiatri and with ties to University of Copenhagen. Our research includes both clinical and basic research studies of the biological basis for psychosis and addictions. You will be working with our fantastic PhD student Simone and alongside other students.

Contact information: If you are interested in the project or have any questions, please contact Morgane Thomsen, morgane.hermann.thomsen@regionh.dk senior researcher at Laboratory of Neuropsychiatry and associate professor at University of Copenhagen, Department of Neuroscience.

Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen, Edel Sauntes Allé 10, 2100 Kbh. Ø.

Start: Fall 2021 or to be agreed upon. Possibility to start with a related individuaised study unit (e.g. spring).

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