Role of NAD+ metabolism in muscle stem cells for skeletal muscle regeneration hos Novo Nordisk Foundation Center for Basic Metabolic Research

Position: This is a project proposal for a student opportunity at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR).

Background: The ability to repair damaged tissue and continuously respond to stressful stimuli is essential to preserve whole-body function throughout life. Muscle stem cells (satellite cells) are an integral part of this process and their loss of function with age contributes to degenerative diseases. NAD+ has emerged as an important and vital cofactor linking energy status with adaptive cellular and organismal responses. Decreasing NAD+ levels could therefore prompt the development of many of the ailments associated with aging. While the levels of NAD+ in skeletal muscle decrease with age, NAD+ levels can be restored by the administration of NAD+ precursors such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN). This also restores lost muscle mass and ameliorates functional defects of aged murine muscles.

The project: We aim to determine how perturbations in NAD+ metabolism in satellite cells affect their ability to proliferate and differentiate, and to regenerate skeletal muscle after damage. We will perform experiments in mice in which NAD+ levels in satellite cells have been manipulated either by genetically targeting of the pathways that generate NAD+ or by providing NAD+ precursors.

The student: You are highly motivated and enthusiastic to learn about muscle stem cells and to perform the experimental and analytical techniques associated with this project.

Contact: Please contact Associate Professor Jonas Treebak (jttreebak@sund.ku.dk) for more information related to this project.

Bemærk: Du skal ofte bruge forhåndsgodkendelse fra dit universitet eller studievejleder for at sikre, at projekter eller specialeopgaver på SDU Jobbank vil blive accepteret som en del af dit studie. Kontakt de relevante aktører i god tid for at sikre, at du vælger det rette projekt.